Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. May cause a lowering of total body sodium (called hyponatremia) elderly people or people taking diuretics or already dehydrated may be more at risk.May trigger an angle-closure attack in certain people at risk of this type of glaucoma. May increase the risk of bleeding, especially if used with other drugs that also increase bleeding risk.Interaction or overdosage may cause serotonin syndrome (symptoms include mental status changes ), fast heart rate, dizziness, flushing, muscle tremor or rigidity, and stomach symptoms (including nausea, vomiting, and diarrhea).May precipitate a manic episode in people with undiagnosed bipolar disorder.Rarely, may cause ECG changes in the heart (particularly in those with pre-existing cardiac disease) and priapism (painful erections lasting more than 6 hours in duration). ![]() Hyponatremia and low blood pressure (particularly when going from a sitting to a standing position) may occur.May cause drowsiness or dizziness and affect a person's ability to drive or operate machinery.May increase the risk of suicidal thoughts or behavior in young adults, children, and teenagers within the first months of treatment (similar to other antidepressants).When the time comes to withdraw trazodone, the dosage should be tapered off slowly under a doctor's advice. Trazodone may cause a discontinuation syndrome if abruptly stopped, symptoms include anxiety, agitation, and sleep disturbances.Dry mouth, headache, constipation, diarrhea, and sexual dysfunction.If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Not classified as a controlled substance.Has not been associated with drug-seeking behavior.Off-label means the use is not FDA-approved, but may be an acceptable use. May be used “off-label” for insomnia (problems with sleeping) in adults.Effective for the treatment of major depressive disorder (MDD).It may also be called a serotonin receptor antagonists and reuptake inhibitor (SARI). Trazodone and nefazodone belong to the class of drugs known as serotonin modulators. ![]() It is structurally related to nefazodone.
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